When Is Mlb Opening Day 2025. Mlb opening day in 2025 is march 27. Here's a look at the 2025 opening day schedule for thursday, march 27.

While there will inevitably be some rainouts, all 30 teams will be in action for mlb’s opening day on thursday, march 27. The tokyo series will be the curtain raiser for the opening day when all 30 teams will be in action.